Regulating effect of Tongxinluo on HIF-1α,VEGF generated by the human brain microvascular endothelial cells induced by β-amyloid1-42
- VernacularTitle:通心络对Aβ_(1-42)损伤人脑微血管内皮细胞HIF-1α、VEGF表达的干预作用
- Author:
Zhihui ZHANG
;
Yiling WU
- Publication Type:Journal Article
- Keywords:
human brain microvascular endothelial cells;
Amyloid β protein;
VEGF;
HIF-1α;
Tongxinluo
- From:
Chinese Pharmacological Bulletin
2010;26(1):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the regulating effect of Tongxinluo on HIF-1α,VEGF that Generated by the Human brain microvascular endothelial cells induced by β-amyloid 1-42.Methods Human brain microvascular endothelial cells were pre-incubated for 4h by Tongxinluo, then injured by β-amyloid 1-42.VEGF protein and HIF-1α were detected by Western blot.Result In the Aβ treated Human brain microvascular endothelial cells,viable cells decreased.The expression of VEGF was Reduced, and HIF-1α elevated. After the cells were treated with Tongxinluo, all the above indexes were improved.Conclusion Tongxinluo can enhance the VEGF protein expressions by the HIF-1α and protect the Human brain microvascular endothelial cells.
