Naringin Inhibits Neuropathic Pain Produced by Lumbar 5 Spinal Nerve Ligation
- VernacularTitle:柚皮苷抑制腰5脊神经结扎引起的神经病理性疼痛
- Author:
Jing WANG
;
Xuhong WEI
;
Weiwei SU
;
Peibo LI
;
Xianguo LIU
- Publication Type:Journal Article
- Keywords:
naringin;
neuropathic pain;
tumour necrosis factor-alpha;
L5 SNL
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effect of naringin at different doses on the neuropathie pain produced by lumbar 5 spinal nerve ligafion (L5 SNL). [Methods] Using the method of behavioral test, we tested the 50% paw withdrawal threshold before and after intragastrieal application of naringin in the rats with L5 SNL. [Results] Naringin at 30, 90, 100 mg/kg but not at 10 mg/kg increased the 50% paw withdrawal threshold of 1.5 SNL rats significantly. Single application of Naringin (at 30 or 90 mg/kg) inhibited mechanical allodynia for around 6 hours, and the inhibitory effect persisted for 4 days after the cessation of the drug when naringin (30 mg/kg, daily) was consecutively applied for 7 days. [Conclusion] Intragastrical of naringin could relieve the neuropathic pain produced by peripheral nerve injury.
