Changes of CD4~+ CD25~+ Regulatory T Cells in Peripheral Blood and Their Relation with Their Body Mass Index of Children with Acute Attack Asthma
- VernacularTitle:哮喘患儿急性发作期CD4~+CD25~+调节性T细胞水平和体质量指数的关系
- Author:
Huarong HUANG
;
Tiantian LIU
;
Baojing WU
;
Weiping TAN
;
Xiandi MAI
- Publication Type:Journal Article
- Keywords:
CD4~+ CD25~+ regulatory T cell;
asthma;
obesity;
body mass index;
flow cytometry;
children
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(1):106-109
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the changes of CD4~+ CD25~+ regulatory T cells (Tr) in peripheral blood and their relation with their body mass index (BMI) of children with acute attack asthma. [Methods] Peripheral blood was obtained from 70 children with acute attack asthma, 30 remission children, and 50 normal control children. Then 70 children with acute attack asthma, were divided by normal weight group (40 cases) and overweight group (30 cases). The levels of CD4~+CD25~+Tr of the patients were tested by flow cytometry (FCM), and their BMI were calculated. [ Results] The levels of CD4~+ CD25~+ Tr [(6.17± 1.72)%] in acute attack group were lower than that in remission group [(7.56±1.48)%] or that in the control group [(7.13± 1.48)%] (P<0.05), but no difference between that in the remission and that in the control (P>0.05). The CD4~+CD25~+Tr of asthmatic children with normal weight [(6.34±1.71)%] was higher than that of asthmatic children with overweight [(4.74±1.20)%] (P<0.05). There was a remarkably negative correlation between the level of CD4~+ CD25~+ Tr of asthmatic children [(6.17±1.72)%] and the BMI (16.00±2.14) (r_p=-0.814, P<0.05). [Conclusion] The levels of CD4~+ CD25~+Tr are remarkable decrease in attack asthmatic children, and more decrease in overweight patients. There is remarkably negative correlation between the levels of CD4~+CD25~+ Tr in peripheral blood of attack asthmatic children and their BMI.
