Association between Interleukin-8 and Apolipoprotein E Gene Polymorphism and Late-onset Alzheimer's Disease
- VernacularTitle:白细胞介素8和载脂蛋白E基因多态性与迟发性阿尔茨海默病的相关分析
- Author:
Yicheng MAI
;
Younian LUO
;
Hong GU
;
Xianwei YAO
;
Lulu ZHANG
;
Hongbo ZHENG
;
Wensheng HU
;
Yan LI
;
Zhongyang WU
;
Jingjing LIN
- Publication Type:Journal Article
- Keywords:
interleukin-8;
apolipoprotein E;
Alzheimer's disease;
gene;
polymorphism
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(1):118-121
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the relation among the polymorphism of interleukin-8 (IL-8) gene A-251T and apolipoprotein E (ApoE) gene with late-onset Alzheimer's disease (LOAD). [Methods] Polymerase chain reaction and restrietive fragment length polymorphism (PCR-RFLP) were used to detect the polymorphism distribution of IL-8 gene A-251T and ApoE gene of 185 people in Han ethnicity of Guangdong province (study group: 88 LOAD patients, eontrolled group: 97 people). The correlation of these genes was analyzed. [Results] (1) The differences of genotypes and alleles of IL-8 gene A-251T between study group and controlled group had no statistical significance. (2) The frequency of ApoE 64 allele in study group was significantly higher than that in controlled group, as risk factor of LOAD (OR=2.272, P=0.003). (3) Study group and controlled group were both divided into two groups by carrying ApoE ε4 allele or not. The differenees of IL-8 genotypes were no significant whether in carrying ApoE ε4 allele group or not (carrying ε4 group: P=0.965; no carrying ε4 group: P=0.523). [Conclusion] It is suggested that lL-8 gene A-251T polymorphism perhaps has no relation with LOAD and has no interaction with ApoE ε4 allele.
