Effect of Cordceps Sinensis on the expression of ICAM-1 and VCAM-1 in the kidney of spontaneously hypertensive rats
10.3969/j.issn.1672-7347.2010.02.011
- VernacularTitle:冬虫夏草制剂对自发性高血压大鼠肾组织ICAM-1和VCAM-1表达的影响
- Author:
Rong WU
;
Qiaoling ZHOU
;
Shudian LIN
;
Xiang AO
;
Xiaomiao CHEN
;
Jinghua YANG
- Publication Type:Journal Article
- Keywords:
hypertensive nephropathy;
intercellular adhesion molecule-1;
vascular cell adhesion molecule-1;
Cordceps Sinensis
- From:
Journal of Central South University(Medical Sciences)
2010;35(2):152-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Cordceps Sinensis (CS) on the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in the kidney of spontaneously hypertensive rats(SHR), and to investigate the mechanism of CS. Methods Male SHRs (23 week old) were randomly divided into 4 groups: a group without any treatment (Group S), a group treated with Cordceps sinensis at 4 F), and a group received daily intragastric administration of CS at 4 male WKY rats were used as normals controls. At the end of 8 weeks, all rats were sacrificed. Serum creatinine(Scr), 24 h urinary protein count, and the expression of ICAM-1 and VCAM-1 were examined by immunohistochemical technique and RT-PCR. Results Compared with the WKY rats, blood pressure, 24 h urinary protein count, Scr,and the expression of ICAM-1 andVCAM-1 in the kidney of SHR significantly increased (P＜0.05).Compared with Group S, blood pressure decreased after treatment by fosinopril (P＜0.05). Compared with Group S, the levels of Scr, 24 h urinary protein count, and glomerular lesion were significantly reduced in the CS and/or fosinopril treatment group. The expression of ICAM-1 and VCAM-1 was significantly decreased in these groups (P＜0.05).Conclusion CS may play a role in the protection and anti-fibrosis in the process of renal injury in SHR through reducing the expression of ICAM-1 and VCAM-1.
