Perfluorocarbon in combination with ligustrazine protects against lung injury during liver transplantation in pigs with hepatopulmonary syndrome
- VernacularTitle:乳化氟碳结合川芎嗪对肝肺综合征猪肝移植围手术期肺部炎症的影响及其机制研究
- Author:
Xuemei PENG
;
Lu XI
;
Yalan LI
;
Zhonghong WANG
;
Huadong WANG
- Publication Type:Journal Article
- Keywords:
Perfluorocarbons;
Hepatopulmonary syndrome;
Ligustrazine;
Lung protection
- From:
Chinese Journal of Pathophysiology
2010;26(1):112-115
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effects of perfluorocarbon and ligustrazine on lung injury during liver transplantation in pigs with hepatopulmonary syndrome. METHODS:A hepatopulmonary syndrome (HPS) model of pig was established by chronic bile duct ligation. The animals were assigned randomly to 2 groups:(1) Perfluorocarbon in combination with ligustrazine treatment groups (PFCL group):the pigs were treated with intratracheal instillation of perfluorocarbon and ligustrazine; (2) The conventional mechanical ventilation group (MV group):all animals were subjected to mechanical ventilation and orthotopic liver transplantation. After 5 h the lungs were harvested for further analysis. RESULTS:The lung wet to dry weight radio,pulmonary permeation index and leukocyte count in bronchoalveolar lavage fluids (BALF) in PFCL group significantly decreased compared to MV group (P<0.05). Contents of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the lung tissue,plasma and BALF of pigs in PFCL group were significantly lower than those in MV group (P<0.05). Moreover,the activation of NF-κB was inhibited markedly by PFCL. CONCLUSION:Perfluorocarbon in combination with ligustrazine effectively reduces the PMN accumulation in the lungs,inhibits TNF-α and IFN-γ production and protects against lung injury during liver transplantation in pigs with hepatopulmonary syndrome.
