Expression of SARS-CoV functional receptor angiotensin-converting enzyme 2 in nephritic epithelium of primates
- VernacularTitle:SARS-CoV功能性受体血管紧张素转换酶2在灵长类动物肾脏上皮细胞的表达
- Author:
Xiuhong YANG
;
Chuan QIN
;
Yunxin CHEN
;
Hua ZHU
;
Lan HUANG
;
Yali LIU
;
Chunmei MA
;
Lianyuan ZHANG
;
Fang YANG
- Publication Type:Journal Article
- Keywords:
Angiotensin-converting enzyme-2;
SARS-CoV;
Nonhuman primate;
Kidney
- From:
Chinese Journal of Pathophysiology
2010;26(1):158-162
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the expression of angiotensin-converting enzyme 2 (ACE2) in nephritic epithelium of primates. METHODS:The expression of ACE2 in Vero E6 cells was detected by the techniques of RT-PCR and immunocytochemistry (ICC) techniques. The distribution of ACE2 protein in kidney tissues of two Rhesus monkeys and two normal human cases was observed by immunohistochemistry (IHC) techniques. RESULTS:Vero E6 cells were found to express both ACE2 mRNA and protein. ACE2 protein was mainly located in epithelium of proximal tubules of Rhesus monkey and human kidney. CONCLUSION:The expression of ACE2 in epithelium of primate kidney may provide the condition for SARS-CoV entry,which may be one of the reasons for inducing renal damage in SARS patients.
