Advances in the research of astrocyte elevated gene-1
- VernacularTitle:Astrocyte elevated gene-1的研究进展
- Author:
Haiyan LIU
;
Xianrang SONG
;
Aiqing ZHENG
;
Ruopeng SUN
- Publication Type:Journal Article
- Keywords:
Astrocyte elevated gene-1;
Neoplasm metastasis
- From:
Chinese Journal of Pathophysiology
2010;26(1):188-192
- CountryChina
- Language:Chinese
-
Abstract:
Astrocyte elevated gene-1 (AEG-1) was cloned as an human immunodeficiency virus -1-inducible and tumor necrosis factor-α-inducible transcript in primary human fetal astrocytes by a rapid subtraction hybridization approach. AEG-1 down-regulates the expression of the glutamate transporter EAAT2, thus, it is implicated in glutamate-induced excitotoxic damage to neurons as evident in HIV-associated neurodegeneration. Meanwhile, AEG-1 expression is elevated in subsets of breast cancer, prostatic cancer, glioblastoma multiforme and melanoma cells, having a dual specificity phosphatase activity. Overexpression of AEG-1 increases and siRNA inhibition of AEG-1 decreases migration and invasion of human glioma cells, respectively. Recent observations indicate that AEG-1 exerts its effects by activating the nuclear factor kappa B (NF-κB) pathway and AEG-1 is a downstream target of Ha-ras and plays an important role in Ha-ras-mediated tumorigenesis. These findings are intensifying interest in AEG-1 as a crucial regulator of tumor progression and metastasis and as a potential mediator of neurodegeneration.
