The effects of promethazine on the analgesia,hypnosis,amnesia and therapeutic index of isoflurane treated mice
- VernacularTitle:异丙嗪对异氟烷小鼠镇痛、催眠、遗忘作用和治疗指数的影响
- Author:
Supei SONG
;
Liuqing HU
;
Chuanfei LIU
;
Zhenheng WANG
;
Yajun LIU
;
Huiming CAI
;
An XIE
;
Xiaolin XU
;
Donghua SHAO
;
Tijun DAI
- Publication Type:Journal Article
- Keywords:
promethazine;
isoflurane;
analgesia;
hypnosis;
amnesia;
therapeutic index;
anesthesia
- From:
Chinese Pharmacological Bulletin
2010;26(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of promethazine on the analgesia,hypnosis,amnesia and therapeutic index of isoflurane.Methods The experiments were designed to study promethazine on the analgesic effect of isoflurane by hot-plate test and writhing test,and to study the effect of promethazine on the sleeping time of isoflurane by the method of righting reflex,and the amnesia of isoflurane by Morris water maze,and the ED_(50),LD_(50) by sequential method in mice.Results The result of hot-plate test and writhing test indicated that promethazine could enhance the analgesic effect of isoflurane(P＜0.05 or P＜0.01);through the experiment of righting reflex, sleeping time of isoflurane in mice was extended by promethazine(P＜0.01);in Morris water maze experiment, the average latency in the combination of promethazine and isoflurane was longer than that of the promethazine group or isoflurane group(P＜0.05 or P＜0.01), while aiming to the residence time, the combination of the two was shorter than that in the third quadrant(P＜0.01 or P＜0.05),the TCPP of the group of isoflurance was more than that of the combination group;promethazine could decrease the ED_(50) of isoflurance(P＜0.01),but it did not obviously affect its LD_(50)(P＞0.05).Conclusion Promethazine can not only reinforce the effect of isoflurance on analgesia,hypnosis and amnesia, but also boost the therapeutic index of isoflurance.
