Cognitive function in healthy first-degree relatives of patients with bipolar Ⅰ disorder
- VernacularTitle:双相障碍Ⅰ型患者健康一级亲属的认知功能
- Author:
Liping CAO
;
Yin LIN
;
Xuan LI
;
Biyu YE
;
Weicheng LIN
;
Zhihua WANG
;
Fengchun WU
;
Jia LI
- Publication Type:Journal Article
- Keywords:
Bipolar disorder First-degree relatives Cognitive function
- From:
Chinese Journal of Nervous and Mental Diseases
2010;36(1):19-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the cognitive function in healthy first-degree relatives (FDRs) of patients with bipolar Ⅰ disorder.Methods Cognitive function were studied in one hundred twenty healthy FDRs of patients with bipolar Ⅰ disorder and one hundred normal controls using digital symbol, digital span, visual reproduction, trail making test A (TMT-A) and trail making test B (TMT-B).Results Compared with normal controls, FDRs showed impairment in all indexes of the tests, including digital symbol, digital span (forward, reversed and forward + reversed), visual reproduction, TMT-A and TMT-B (t=-3.44、-4.23、-4.32、-4.98、-2.59、4.32、3.78, respectively, Ps≤0.01).By analysis of covariance (covariant: age and years of education), FDRs were still impaired in these indexes (P<0.05).Compared with sex-matched normal controls, male FDRs showed impairment in all indexes of the tests, but female FDRs only showed impairment in digital span (reversed, forward + reversed), TMT-A and TMT-B (P<0.05).Conclusions Attention, memory and executive function are impaired in healthy first-degree relatives of patients with bipolar Ⅰ disorder.
