Establishment and Comparison of Two Mouse Models of Celiac and Cervical Heterotopic Heart Transplantation
- VernacularTitle:两种异位心脏移植小鼠模型的建立和比较
- Author:
Yifa CHEN
;
Hui YIN
;
Binyong LIANG
;
Zhiyuan HUANG
;
Hongliang LIU
;
Xiaoping CHEN
;
Feili GONG
- Publication Type:Journal Article
- Keywords:
Heart transplantation;
celiac;
Heart transplantation;
cervical;
Animal model;
Mouse
- From:
Acta Laboratorium Animalis Scientia Sinica
2010;18(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective Objective In order to better keep up with the development of transplantation immunobiology.we established and compared two types of mouse heterotopic heart transplantation,and hope to help further organ transplantation studies.Methods According to the surgical procedures of Ono's type and Chen's type of mouse model of heterotopic heart transplantation with some modification,we performed celiac and cervical heteropotic heart transplantation between iso-strains and hetero-strains,and compared the operation suecess rate,operation time,allografi survival time,and histopathology of those establishment methods.Results The success rates of mouse celiac and cervical heterotopic heart transplantation were 86.7% and 83.3%,respectively,with a non-significant difference(P>0.05) between the two methods of operation regarding the total operation time,survival time of the allografts,and histopathological findings.Conclusions Based on the mastery of microsurgical techniques,the two models of heterotopic mouse heart transplantation can be established equally,and either of them can be considered depending on the particular requirements of studies.
