Effect of cytokines secreted from Kupffer cell on HSC proliferation, apoptosis in hepatic fibrosis process
- VernacularTitle:肝纤维化病程中Kupffer细胞分泌的细胞因子对肝星状细胞活化增殖、凋亡的调控
- Author:
Yan HUANG
;
Cheng HUANG
;
Jun LI
- Publication Type:Journal Article
- Keywords:
HSC;
Kupffer cell;
cytokine;
hepatic fibrosis;
proli feration;
apoptosis
- From:
Chinese Pharmacological Bulletin
2010;26(1):9-13
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis can be caused by chronic liver injury arising from various etiological factors and it is a reversible process.The activation of the hepatic stellate cell(HSC)is the central event in liver fibrosis,since we know that cytokines secreted from Kupffer cell participate in HSC proliferation,apoptosis and ECM metabolism.In this paper we focus on the relationship between HSCs,Kupffer cell,cytokines and the course of hepatic fibrosis.Elucidating this relationship will benefit research on the role of Kupffer and HSCs in hepatic fibrosis.
