Effect of 6% hydroxyethyl starch 130/0.4 and Ringer's solution resuscitation on early lung injury in hemorrhagic shock rats
- VernacularTitle:羟乙基淀粉130/0.4不同复苏方案对失血性休克大鼠肺损伤的早期影响及机制
- Author:
Huaqin LIU
;
Yong LI
;
Xiangdong LIU
;
Yuying XING
;
Jianfeng FU
;
Shijie WANG
- Publication Type:Journal Article
- Keywords:
hydroxyethyl starch;
fluid resuscitation;
hemorrhagic shock;
respiratory distress syndrome;
adult;
neutrophils
- From:
Chinese Pharmacological Bulletin
2010;26(1):99-103
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of 6% hydroxyethyl starch 130/0.4(6%HES 130/0.4)and Ringer's solution resuscitation on early lung injury in hemorrhagic shock rats and its mechanisms.Methods Twenty-four male SD rats were divided into 4 groups:sham,Ringer's solution(RS),two HES groups(H1,H2).Group H1,H2 received HES 33,50 ml·kg~(-1) and Ringer's solutions respectively after 90-minute shock(the dose of Ringer's solutions was 3 times as muchas the maximum shed blood volume minus the dose of HES).Blood samples were taken from artery for blood analysis and the expression of CD11b/CD18 at T_0,T_1,T_4,T_5.The lungs were removed for ultrastructure examination.Results PaO_2 increased in group H1 at T_(1～5) and group H2 at T_5 as compared with T_0.PaCO_2 decreased in all the resusitation groups.The ultrastructure was basically normal except that the mitochondria changed slightly in group H1.In group H2,the perinuclear space was dilated slightly and the rough endoplasmic reticulum expanded slightly,and the degranulation was observed.Compared with group RS,the expressions of CD11b and CD18 decreased at T_4,T_5;compared with group H1,the expressions of CD11b and CD18 in group H2 increased.Conclusions Treatment with 6%HES(130/0.4)33 ml·kg~(-1)and Ringer's solution can attenuate hemorrhagic shock,and the resuscitation reduces lung injury through inhibition of expressions of CD11b and CD18.
