Correlation between Hyperghrelinemia and Carotid Artery Intima-Media Thickness in Children with Prader-Willi Syndrome.
10.3349/ymj.2010.51.3.339
- Author:
Su Jin KIM
1
;
Kyung Hoon PAIK
;
Dong Ik KIM
;
Yon Ho CHOE
;
Seon Woo KIM
;
Dong Kyu JIN
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jindk@skku.edu
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Intima-media thickness;
ghrelin;
Prader-Willi syndrome;
risk factors;
atherosclerosis
- MeSH:
Adolescent;
Carotid Arteries/*pathology;
Child;
Female;
Ghrelin/*blood;
Humans;
Male;
Prader-Willi Syndrome/*blood/*pathology;
Tunica Intima/*pathology;
Tunica Media/*pathology
- From:Yonsei Medical Journal
2010;51(3):339-344
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability. The objective of the study is to assess the relationship between carotid intima-media thickness (IMT) and atherosclerotic risk factors. MATERIALS AND METHODS: Twenty-seven PWS children and 24 normal controls were enrolled. Correlations of IMT with atherosclerotic risk factors were assessed. RESULTS: IMTs in the PWS group did not differ from those in the controls (p = 0.172), although total ghrelin levels were higher in the PWS children (p = 0.003). The multivariate analysis revealed positive correlations between total ghrelin levels (rho = 0.489, p = 0.046) and IMT in the PWS group and between body mass index-standard deviation score (BMI-SDS) (rho = 0.697, p = 0.005) and IMT in the controls. CONCLUSION: Considering the positive correlation of IMT with total ghrelin levels and the high level of ghrelin in PWS children, a further study is warranted to evaluate the role of elevated ghrelin on atherosclerosis for PWS.
