Research progress of mechanisms of Acinetobacter baumannii resistance to β-lactam antibiotics
- VernacularTitle:鲍曼不动杆菌对β-内酰胺类抗生素耐药机制的研究进展
- Author:
Panfei HOU
;
Chunmei YING
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
carbapenem-resistant;
β-lactam antibiotics;
resistance mechanisms
- From:
Journal of Shanghai Jiaotong University(medical Science)
2010;30(1):98-103
- CountryChina
- Language:Chinese
-
Abstract:
Acinetobacter baumannii, a glucose-nonfermentative gram-negative coccobacillus, is an important pathogen isolated in nosocomial infections, and the clinical detection rate has been increasing in recent years. Acinetobacter baumannii attracts widespread attention due to strong viability, broad resistance spectrum and high rate of drug resistance. The resistance mechanisms include the production of β-lactamases, alterations in penicillin-binding proteins, decreased outer membrane permeability and overexpression of active efflux pumps. The mechanisms of Acinetobacter baumannii resistance to β-lactarn antibiotics, especially those of the outer membrane porin and active efflux system are reviewed in this paper.
