Research advances in peroxisome proliferator activated receptor-γ and renal fibrosis
- VernacularTitle:过氧化物酶体增殖物激活受体-γ与肾脏纤维化的研究进展
- Author:
Ying LU
;
Weiming WANG
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator activated receptor-γ;
chronic kidney disease;
glomerular sclerosis;
renal interstitial fibrosis
- From:
Journal of Shanghai Jiaotong University(medical Science)
2010;30(1):104-107
- CountryChina
- Language:Chinese
-
Abstract:
The end stage of chronic renal diseases is characterized by glomerular sclerosis and interstitial fibrosis. Studies have revealed that effective amelioration of renal fibrosis can significantly delay the progression of chronic renal diseases. Peroxisome proliferator activated receptors (PPARs) are ligand-activated nuclear transcriptional factors of the nuclear hormone receptor superfamily, and PPAR-γ is one of the phenotypes of PPARs. The effect of PPAR-γ on inhibiting renal fibrosis has become a hot spot. In this article the research advances of PPAR-γ in amelioration of renal fibrosis are reviewed.
