Function of P2 receptors in skeletal muscle and their roles in the diseases
- VernacularTitle:骨骼肌P2受体的功能与疾病
- Author:
Changshui XU
;
Yun GAO
;
Shangdong LIANG
- Publication Type:Journal Article
- Keywords:
P2 receptors;
extracelluar purine nucleotides;
extracelluar pyrimidin nucleotides;
skeletal muscle;
neuromuscular junctions;
skeletal muscle disease
- From:
Chinese Pharmacological Bulletin
2010;26(2):144-147
- CountryChina
- Language:Chinese
-
Abstract:
P2 receptors activated by purine and pyrimidine nucleotides are divided into two subclasses:P2Y receptors which are G-protein coupled and P2X receptors which are ligand-gated ion channels.The expression of specific P2X and P2Y receptor subtypes in skeletal muscle cells has been demonstrated.Purinergic signaling plays an important role in muscle regeneration of muscular dystrophy,and is involved in skeletal muscle diseases such as muscular dystrophy,tendon inflammation and epilepsy,and provides the possibility of new therapeutic strategies for the treatment of muscle diseases.
