Function study of acid-sensing ion channels in non-neuronal tissues
- VernacularTitle:酸敏感离子通道在非神经组织中的功能研究
- Author:
Fenglai YUAN
;
Feihu CHEN
;
Weiguo LU
;
Xia LI
;
Fanrong WU
;
Tongyue ZHANG
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
acid-sensing ion channels;
functions;
acidosis;
nervous system;
non-neuronal tissues
- From:
Chinese Pharmacological Bulletin
2010;26(2):147-150
- CountryChina
- Language:Chinese
-
Abstract:
Acid-sensing ion channels(ASICs) are a novel class of ligand-gated cation channels activated by extracellular acidification and belong to the epithelial sodium channels(DEG/ENaC) superfamily.Their biological functions have recently been found not only in the central nervous system but also relevant to the physiology and pathology of non-neuronal tissues such as taste buds, cardiovascular system and bones.This review concerns the latest research on the expression and functions of ASICs in non-neuronal tissues so as to promote the understanding of their physiological and pathological functions.
