Research progress in osteopontin and pulmonary fibrosis
- VernacularTitle:骨桥蛋白与肺纤维化的研究进展
- Author:
Haibiao HE
;
Zhenlun GU
;
Xiaogang JIANG
;
Wenxuan ZHOU
;
Ciyi GUO
- Publication Type:Journal Article
- Keywords:
osteopontin;
pulmonary fibrosis;
extracellular matrix;
fibroblast;
alveolar epithelial cell;
epithelial-mesenchymal-transition;
signal transduction
- From:
Chinese Pharmacological Bulletin
2010;26(2):151-155
- CountryChina
- Language:Chinese
-
Abstract:
Osteopontin (OPN) is a secreted O-glycosylated phosphoprotein that exists in a variety of tissues and body fluids, with a variety of biological activity. Integrin α_vβ_3 is the main receptor. OPN mainly involves in cell proliferation, differentiation, migration and adhesion. The study of OPN at home and abroad mainly focuses on the bone resorption, angiogenesis, atherosclerosis, digestive system, urinary system, wound healing, skin fibrosis, liver fibrosis, kidney fibrosis, etc.But reports about OPN in pulmonary fibrosis are much less, now the relationships between OPN and pulmonary fibrosis are reviewed.
