Application of population pharmacokinetics in the rational usage of immunosuppressive drugs
- VernacularTitle:群体药动学在免疫抑制剂合理用药中的应用
- Author:
Bing CHEN
;
Weimin CAI
- Publication Type:Journal Article
- Keywords:
population pharmacokinetics(PPK);
immunosuppressive drugs;
cyclosporine A;
tacrolimus;
myphonolic acid;
sirolimus
- From:
Chinese Pharmacological Bulletin
2010;26(2):159-163
- CountryChina
- Language:Chinese
-
Abstract:
Population pharmacokinetics(PPK),which is based on the principle of statistics,can be used to estimate various inter- and intra-individual factors which affect pharmacokinetics.By using Bayesian estimator,PPK can predict individual pharmacokinetic parameters accurately.PPK is widely used in the immunosuppressive therapy with cyclosporine,tacrolimus,mycophenolic acid and sirolimus.
