Therapeutic Effect of Repeated Hepatectomy on 48 Cases of Recurrent Hepatocellular Carcinoma and Prognostic Factors
10.3969/j.issn.1000-8179.2010.02.009
- VernacularTitle:48例复发性肝细胞癌再次切除术后的疗效及预后因素分析
- Author:
Xiaojing CHEN
;
Kai ZHOU
;
Binkui LI
;
Liang HUANG
;
Jinqing LI
;
Yaqi ZHANG
;
Yunfei YUAN
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Recurrence;
Repeated hepatectomy;
Prognosis
- From:
Chinese Journal of Clinical Oncology
2010;37(2):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the therapeutic effect of repeated hepatectomy on recurrent hepatocellu-lar carcinoma and prognostic factors. Methods: We retrospectively analyzed the clinicopathologic data of 48 patients who underwent repeated hepatectomy for recurrent hepatocellular carcinoma between July 1995 and July 2003. Overall survival rate and disease-free survival (DFS) rate were calculated by Kaplan-Meier meth-od. Prognostic factors were analyzed by univariate and multivariate analysis. Results: The median survival of 48 patients was 36.4 months. The overall 1-, 3-, and 5-year survival rates were 81.3%, 45.8%, and 27.1%, re-spectively. The disease-free 1-, 3-, and 5-year survival rates were 70.8%, 25.0%, and 16.7%, respectively. Univariate analysis showed that TNM stage of primary tumor, TNM stage of the recurrent tumor, vascular in-vasion, recurrent tumor size (>5cm) and recurrence-free interval were prognostic risk factors for overall surviv-al. While TNM stage of primary tumor, recurrent tumor size (>5cm), TNM stage of recurrent tumor, vascular in-vasion, pathological grading of recurrent tumor, preoperative AFP and recurrence-free interval were prognos-tic risk factors for DFS. Multivariate analysis showed that recurrence-free interval and TNM stage of recurrent tumor were independent prognostic risk factors for overall survival. While recurrence-frae interval and recur-rent tumor size (>5cm) were independent prognostic risk factors for DFS. Conclusion: Short recurrence-free in-terval (≤24 months), recurrent tumor size (>5cm) and TNM stage of recurrent tumor indicate poor prognosis of patients who received repeated hepatectomy for recurrent hepatocellular carcinoma.
