The cause of atherosclerosis:secretory dysfunction in vascular endothelial cells and proliferation of smooth muscle cells
- VernacularTitle:动脉粥样硬化血管内皮分泌功能失调与平滑肌细胞增殖
- Author:
Lei LI
;
Min DAI
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
vascular endothelial cell;
smooth muscle cell;
growth factor;
cytokines;
vascular substances;
uproliferation
- From:
Chinese Pharmacological Bulletin
2010;26(2):155-158
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial cells and smooth muscle cells,structurally and functionally closely related,are two main cells of vascular wall.While the interaction between cycling factors and vascular wall cells can lead to the occurrence of atherosclerosis.The injury of endothelial cells results in secretory dysfunction and abnormal proliferation of smooth muscle cells which narrows the cavity of blood vessel and cause spasm.This is the common pathological basis of the occurrence and development of atherosclerosis and other vascular diseases.In the pathological state of atherosclerosis,the proliferation of smooth muscle cell will be affected by what the vascular endothelial cells secrete,like growth factors,cytokines,and vasoactive substances.This paper gives a comprehensive overview of the latest research advances in this field.
