Relationship between pelvic floor dysfunction and serum relaxin H2 and expression of vaginal wall relaxin receptor LGR7 mRBA in late pregnant women
- VernacularTitle:妊娠晚期盆底功能障碍与血清松驰素H2质量浓度和阴道壁松驰素受体LGR7 mRNA表达的关系
- Author:
Li JIANG
;
Qingkai WU
;
Laimin LUO
;
Jie FENG
- Publication Type:Journal Article
- Keywords:
pregnancy;
pelvic floor dysfunction;
relaxin;
relaxin receptor LGR7
- From:
Journal of Shanghai Jiaotong University(medical Science)
2010;30(2):165-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between pelvic floor dysfunction and serum relaxin H2 and expression of vaginal wall relaxin receptor LGR7 mRNA in late pregnant women. Methods Before the beginning of delivery,all women were evaluated by pelvic organ prolapse quantitation(POP-Q)scoring.Twelve women with stress urinary incontinence(SUI)and stage II prolapse of anterior vaginal wall were selected as patient group,and another 24 women without SUI and prolapse of pelvic floor were served as control group.Serum relaxin H2 was determined by ELISA.Vaginal wall tissues were taken after vaginal delivery,and the expression of relaxin receptor LGR7 mRNA was detected by RT-PCR.Results The serum level of relaxin H2 and expression of LGR7 mRNA of vaginal tissues in patient group were significantly higher than those in control group(P<0.01,P<0.05). Conclusion The increased level of serum relaxin and expression of vaginal wall relaxin receptor may correlate with the pelvic floor dysfunction in late pregnant women.
