Correlation analysis of cytochrome P450c19 genes with osteoporotic fracture in a large sample of Shaanxi Guanzhong Population
- VernacularTitle:陕西关中人群骨质疏松性骨折与细胞色素P450芳香化酶编码基因的关联分析
- Author:
Jintang WANG
;
Shixun WU
;
Yunhui JIA
- Publication Type:Journal Article
- Keywords:
osteoporosis;
cytochrome P450c19 (CYP19) gene;
single nucleotide polymorphism;
haplotye;
fracture
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
2010;31(2):160-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between osteoporotic hip fracture (OHF) and polymorphism of cytochrome P450c19 genes. Methods By using a group correlation analysis, we made a case-control study of seven single nucleotide polymorphism (SNP) sites groupinge and haplotype in 400 OHF patients from Shaanxi Guanzhong population and 400 normal samples as controls. Results A total of 700 samples were successfully genotyped. Correlation analysis identified three blocks and selected seven tag SNPs. According to the variance analysis, rs7167343, rs8031463, and polymorphism of haplotype 3 were associated with hip fracture. Conclusion Cytochrome P450c19 genes have association with the incidence of osteoporotic fracture in the Han population we studied from Shaanxi Guanzhong region. Therefore, cytochrome P450c19 genes may affect the incidence of osteoporotic hip fracture in the Han population from Guanzhong region, Shaanxi Province.
