Research progress in prorenin and prorenin receptor
- VernacularTitle:肾素原及其受体的研究进展
- Author:
Xiaohui YANG
;
Xinzheng LU
- Publication Type:Journal Article
- Keywords:
Prorenin;
Receptors;
prorenin;
Renin-angiotensin system;
Signal transduction
- From:
Chinese Journal of Pathophysiology
2010;26(2):405-408
- CountryChina
- Language:Chinese
-
Abstract:
The renin-angiotension system (RAS) plays an important role in cardiovascular and renal physiology and diseases. Recent discoveries of prorenin and prorenin receptor add new contents to RAS. Renin and prorenin binding to the prorenin receptor not only target and facilitate angiotensin generation but also lead to activation of prorenin receptor signal transduction pathways, which is distinct from classical RAS signaling. In this paper, the construction, function and signal trasduction of prorenin, prorenin receptor and handle region peptide are reviewed.
