The enhancement of Astragalus Polysaccharide on specific immunotherapy in asthmatic mouse
- VernacularTitle:黄芪多糖对哮喘小鼠特异性免疫治疗的增强作用
- Author:
Zeqing SONG
;
Lin LIN
;
Yanfen ZHU
- Publication Type:Journal Article
- Keywords:
Asthma;
SIT;
APS;
Th1/Th2
- From:
Chinese Journal of Immunology
2010;26(2):132-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects the of Astragalus Polysaccharide on specific immune therapy in a mouse model of asthma.Methods:Ninety SPF(Specific pathogen Free) BALB/c mice were randomly divided into six groups.The experimental groups were sensitized with OVA,treated with SIT or APS or their joint application.Then the mice were excited with 1% OVA.24 hours after the last excition,the numbers of the total inflammation cells and esoinophils(EOS) in BALF were counted.The left lung tissues were used to perform histological analysis.IFN-γ and IL-4 in peripheral blood were analysed by ELISA.Results:After the therapy,asthma-associated lung inflammation was inhibited,and the numbers of total cells and EOS decreased.IFN-γ level was raised and IL-4 level was lowered.Conclusion:APS can enhance SIT.It may result from affecting production of both the IFN-γ and IL-4.
