The preliminary research of relationship between Toll-like receptor and the immunoloregulation of Sertoli cell
- VernacularTitle:Toll样受体对睾丸Sertoli细胞免疫调节的初步研究
- Author:
Xiuzhi LIU
;
Yebin XI
;
Rongping LI
;
Guangjie CHENG
;
Baoguo WANG
;
Lihua JIANG
;
Weiyi LI
- Publication Type:Journal Article
- Keywords:
Rat;
Toll-like receptor;
Sertoli cell;
Immunoloregulation
- From:
Chinese Journal of Immunology
2010;26(2):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between Toll-like receptor and the immune regulation about inflammation by Sertoli cell in vitro.Methods:Here we examined the expression and potential functions of TLR family in rat Sertoli cells.Using our well-characterized urealyticum(UU) induced model we tested the expression changes of TLR2 and TLR6 at 12~(th),24~(th),36~(th) hours after UU infection in vitro.Results:We demonstrated that TLR2-8 are highly expressed;TLR9 and TLR10 are expressed at relatively low level;the expression of TLR1 and TLR5 are not detected in normal rat Sertoli cells.Comparing with control group,Sertoli cells express more TLR2 and TLR6 after infected by UU.Conclusion:There is some relationship between the activation of TLRs and the immune regulation about inflammation by Sertoli cell.
