Effect of MECT on learning memory in depressed rats and its synaptic plasticity mechanism
- VernacularTitle:无抽搐电休克对抑郁大鼠学习记忆功能的影响及其突触可塑性机制
- Author:
Yuanyuan LIU
;
Su MIN
;
Jun DONG
;
Jun CAO
;
Ping LI
;
Yongfeng LIU
- Publication Type:Journal Article
- Keywords:
Depression;
Electroconvulsive therapy;
Synaptophysin;
Synaptic plasticity
- From:
Chinese Journal of Nervous and Mental Diseases
2010;36(2):70-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of MECT on learning memory in depressed rats and its synaptic plasticity mechanism. Methods Fifty SD rats were randomly divided into 5 groups( n =10): MECT (received ECT with intraperitoneal propofol), ECT (received ECT only), propofol (received intraperitoneal propofol), depression, and control. The treatments were given daily for 7 consecutive days. All rats underwent open field and Morris water maze test. The SYP protein and mRNA expressions in rat hippocampus were detected using immunochemistry and RT-PCR, respectively. Results After treatment, the open field scores were much higher in MECT and ECT groups than in propofol and depression groups ( P <0.05); the learning memory was worse in ECT group than in MECT, propofol and depression groups ( P <0.05); the expressions of SYP protein and mRNA was higher in MECT and ECT groups than in propofol and depression groups ( P <0.05), the expressions of SYP protein and mRNA were lower in MECT group than ECT group ( P <0.05). Conclusions Propofol can improve learning memory in ECT-treated depressed rats through attenuation of ECT-induced expression of SYP in rat hippocampus.
