Progress in mechanisms of methamphetamine-induced dopaminergic neurotoxicity
- VernacularTitle:甲基苯丙胺致多巴胺能神经元毒性机制的研究进展
- Author:
Xiaofeng ZENG
;
Gang LU
;
Zhen LI
- Publication Type:Journal Article
- Keywords:
forensic pathology;
methamphetamine;
neurotoxicity;
dopamine
- From:
Chinese Journal of Forensic Medicine
2010;25(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Methamphetamine is a powerful stimulant of amphetamine type in the central nervous system (CNS),and recently it has become the major drugs of abuse.A lot of research results show that MA may induce dopaminergic neurotoxicity in the animal and human striatum.The mechanisms include effects on dopaminergic signaling and dopamine oxidation,glutamate induced excitotoxicity,oxidative stress and inflammatory cytokines,disruption of mitochondfia,apoptosis,activation of glial cells and hyperthermia.However the mechanisms by the MA-induced dopaminergic neurotoxicity are not completely understood.The paper reviewed recent progress of study on them to provide reference materials for related research.
