Effects of gabapentin on plasma β-endorphin level in the patients with painful diabetic neuropathy
10.3969/j.issn.1006-6187.2010.01.013
- VernacularTitle:加巴喷丁对糖尿病神经痛患者血浆β内啡肽水平的影响
- Author:
Xiaoning YANG
;
Hua XU
;
Yanfei MAO
;
Maojin XU
;
Hui CHEN
;
Yuanchang XIONG
- Publication Type:Journal Article
- Keywords:
Gabapentin;
Diabetes mellitus;
Painful diabetic neuropathy;
β-endorphin
- From:
Chinese Journal of Diabetes
2010;18(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of gabapentin(GBP) on plasma β-endorphin(β-EP) level in the patients with painful diabetic neuropathy(PDN). Methods We detected the plasma β-EP level in 24 PDN patients in the treatment with GBP, 18 PDN patients without GBP treatment, 20 diabetic mellitus patients without PDN and 24 healthy control subjects. Results (1)The level of β-EP in diabetic mellitus patients was lower than in the healthy control(P<0.01). (2)The patients who received GBP had a significant change of β-EP level after treatment(P<0. 01).. Conclusions Gabapentin is effective for the treatment of PDN and its adverse effects are mild. It can lower the plasma β-EP level in the patients with PDN.
