Association between MDM2 SNP309 Polymorphism and Breast Cancer Risk in Chinese Women

VernacularTitle:MDM2启动子区309位点基因多态性与乳腺癌风险的关系
Author: Can WU ; Ye XU ; Tao OUYANG ; Jinfeng LI ; Fianfeng WANG ; Zhaoqing FAN ; Tie FAN ; Benyao LIN ; Yuntao XIE
Publication Type:Journal Article
Keywords: MDM2; Single nucleotide polymorphism; Breast cancer; Risk
From: Chinese Journal of Clinical Oncology 2010;37(3):131-133
CountryChina
Language:Chinese
Abstract: Objective: To investigate the correlation of MDM2 SNP309 polymorphism with breast cancer risk in Chinese women. Methods: The polymorphism of MDM2 SNP309 was detected by PCR-restriction frag-ment length polymorphisms assay (PCR-RFLP) in 698 women with primary breast cancer and 525 healthy controls. Results: Compared with the T/T genotype, the G allele (T/G or G/G) was not associated with an in-creased risk of breast cancer in the entire population studied (T/G, adjusted OR=1.2, 95% CI: 0.8-1.6, P=0.30; G/G, adjusted OR=1.0, 95% CI: 0.7 ～ 1.5, P=0.88). Among postmenopausal women, the G allele (T/G or G/G) was significantly associated with an increased risk of breast cancer (T/G, adjusted OR=1.8, 95% CI:1.2～3.0, P=0.011; G/G, adjusted OR=1.9, 95% CI: 1.2～3.3, P=0.014). But this association was not ob-served among premenopausal women. Conclusion: MDM2 SNP309 heterozygous T/G genotype and homozy-gous mutant GIG genotype increase breast cancer risk in postmenopausal Chinese women.