The Relationship of nm23 and VEGF Expression with Lymph Node Micrometastasis of Stage Ⅰ Non-small Cell Lung Cancer
10.3969/j.issn.1000-8179.2010.03.008
- VernacularTitle:Ⅰ期非小细胞肺癌nm23 VEGF表达与淋巴结微转移关系的研究
- Author:
Xiaoling LI
;
Liqun CHEN
;
Bin LIU
;
Mingyao WANG
;
Yi LI
- Publication Type:Journal Article
- Keywords:
nm23;
VEGF;
Lymph node micrometastasis;
Stage Ⅰ NSCLC
- From:
Chinese Journal of Clinical Oncology
2010;37(3):148-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship of nm23 and VEGF expression with hilar lymph node micrometastasis and the prognosis of stage Ⅰ non-small cell lung cancer (NSCLC). Methods: Immunohisto-chemistry was used to detect nm23 and VEGF protein expression in primary cancer tissue and cytokeratins in 86 hilar lymph nodes from 40 patients with stage Ⅰ NSCLC. Kaplan-meier method and Log rank test were used to analyze the 5-year survival. Results: The rate of positive hilar lymph node micrometastasis was 12.5% for stage Ⅰ NSCLC. Lymph node micrometastasis was not statistically correlated with gender, age, histologic type, differentiation, primary tumor size or VEGF protein expression (P>0.05). But it was reversely associated with nm23 protein expression in primary cancer tissue of NSCLC (P<0.05). The 5-year overall survival of pa-tients with well-differentiated NSCLC, positive nm23 expression and negative lymph node micrometastasis was better than those with moderately and poorly differentiated NSCLC, negative nm23 expression and posi-tive lymph node micrometastasis (P<0.05). Lymph node micrometastasis and nm23 protein expression were identified as two independent prognostic factors for stage Ⅰ NSCLC by univariate Cox regression analysis.Conclusion: nm23 protein expression in pdmary cancer tissue of stage Ⅰ NSCLC is closely associated with hi-lar lymph node micrometastasis, nm23 protein and hilar lymph node micrometastasis are two independent prognostic factors for stage Ⅰ NSCLC. Patients with nm23 protein deletion and positive lymph node microme-tastasis have a poor prognosis.
