Effects of 3-deoxyglucosone on blood glucose of normal mice
10.3969/j.issn.1006-6187.2010.03.019
- VernacularTitle:3-脱氧葡萄糖醛酮对正常小鼠血糖的影响
- Author:
Qian WANG
;
Guorong JIANG
;
Lurong ZHANG
- Publication Type:Journal Article
- Keywords:
3-DG;
Mice;
Blood glucose;
Glucose tolerance;
Diabetic mellitus
- From:
Chinese Journal of Diabetes
2010;18(3):220-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of exogenous 3-deoxyglucosone (3-DG) on blood glucose of normal mice. Methods Kunming male mice were divided into two groups: 3-DG (5mg/kg) treatment and control group.At day 1,week 1 and week 2 after treatment, we compared fasting blood glucose,and did the glucose tolerance test in 3-DG group after 2 weeks' 3-DG administration. Results Blood glucose was increased obviously 2h after administration with 3-DG once versus pre-administration and control (7.78±0.694 vs 6.41±0.408,and 6.43±0.43,all higher than control,but no statistical significance (P＞0.05). There were no differences in 6 hour fasting blood glucose after once administration with 3-DG and in 12 hours fasting blood glucose two weeks after administration with 3-DG between 3-DG and Con groups. After 3-DG administration for two weeks,as compared with Con, the 30 minute blood glucose of 3-DG administration mice during OGTT was obviously increased (19.47±1.541 vs 17.22±1.911,P＜0.05), but glucose levels at 60 minute and 120 minute had no changes (P＞0.05). Conclusions Exogenous 3-DG increases the normal mice's blood glucose immediately after once administration with 3-DG and results in up-moving of glucose physiological curve and leads to a light impairment of glucose tolerance when mice were continuously fed with 3-DG for 2 weeks.
