Canonical Wnt pathway and schizophrenia
- VernacularTitle:经典Wnt信号通路与精神分裂症
- Author:
Xuemei WANG
;
Donghong CUI
;
Zeping XIAO
- Publication Type:Journal Article
- Keywords:
canonical Wnt pathway;
schizophrenia;
neurodevelopment
- From:
Journal of Shanghai Jiaotong University(medical Science)
2010;30(2):225-228
- CountryChina
- Language:Chinese
-
Abstract:
Schizophrenia is one of the most severe psychiatric disorders.Although the etiology is unknown,schizophrenia appears to be a polygenic disorder associated with environmental factors.There are evidences that intracellular signaling plays an important role in the pathogenesis of schizophrenia.Canonical Wnt pathway,which is closely related to the development and function maintenance of central nervous system,have drawn wide attention.Evidences for potential disturbances of Wnt signaling pathways in schizophrenia have accumulated,which are in favour of the hypothesis that Wnt signaling alterations may be important in the pathogenesis of schizophrenia.The research advances in the relationship between canonical Wnt signaling pathway and schizophrenia are reviewed in this paper.
