Clinical Value of Growth Factors and Their Receptors for the Metastasis and Prognosis of Breast Cancer
10.3969/j.issn.1000-8179.2010.04.017
- VernacularTitle:生长因子及其受体作为乳腺癌转移与预后血清标志物的临床价值
- Author:
Yuanyuan XU
;
Yumei FENG
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Prognosis;
Growth factor;
Growth factor receptor;
Serum tumor markers
- From:
Chinese Journal of Clinical Oncology
2010;37(4):234-237
- CountryChina
- Language:Chinese
-
Abstract:
Through its high affinity with membrane receptors, growth factors promote tumor growth, metastasis and an-giogenesis, induce the change of tumor microenvironment and regulate immune response. It has been demonstrated that the serum protein levels of epidermal growth factor and its receptor, transforming growth factors and their receptors, insu-lin-like growth factors, and angiogenesis factors may have predictive value for metastasis and prognosis of breast cancer. Detecting serum levels of growth factors and their receptors which have synergistic effect or interaction with each other may be helpful for predicting the metastasis and progression of breast cancer.
