Enantioseparation of 38 Racemates on Four Chiral Columns in High Performance Liquid Chromatography
10.3724/SP.J.1096.2010.00181
- VernacularTitle:高效液相色谱的4种商品手性柱对38种手性化合物的拆分研究
- Author:
Mei ZHANG
;
Wenhui XI
;
Min ZI
;
Ya PENG
;
Shengming XIE
;
Liming YUAN
- Publication Type:Journal Article
- Keywords:
Cellucose tris-(3;
5-dimethyphenylcarbamate);
Amylose tris-(3;
5-dimethyphenylcarbamate);
(S;
S)-Whelk-01;
Chiral stationary phases;
Enantioseparation
- From:
Chinese Journal of Analytical Chemistry
2010;38(2):181-186
- CountryChina
- Language:Chinese
-
Abstract:
The enantioseparations of 38 racemates on Chiralcel OD, Chiralpak AD, Chiralpak IA and(S, S)-Whelk-01 were presented by HPLC. Those enantiomers come from the amines, alcohols, ethers, ketones, aromatic derivatives, heterocyclic compounds, amide acids and medicines etc. With the mobile phase of n-hexane)/isopropanol(90∶ 10, V/V), n-hexane/isopropanol/trifluoracetic acid(90∶ 10∶ 0.2, V/V) or n-hexane/isopropanol/triethylamine(90∶ 10∶ 0.2, V/V), over 70% enantioseparations were obtained for OD, AD and IA columns). The order of enantioseparation selectivity for four columns was OD>AD>IA>(S,S)-Whelk-01, and among those columns there was a big chiral discriminating complementarity. This investigation was useful for choosing chiral columns to separate chiral compounds.
