Research advances of phosphokinases for α-synuclein
10.3867/j.issn.1000-3002.2009.06.011
- VernacularTitle:α突触核蛋白磷酸激酶的研究进展
- Author:
Yuanyuan ZENG
;
Zhongqin LIANG
- Publication Type:Journal Article
- Keywords:
α-synuclein;
phosphokinase;
protein kinase;
Parkinson disease
- From:
Chinese Journal of Pharmacology and Toxicology
2009;23(6):485-489
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal aggregation of α-synuclein(α-Syn) is thought to be a key event in the pathogenesis of Parkinson disease (PD). In recent years, it was shown that above 90% of α-Syn deposited in Lewy bodies in brain tissues from patients with PD is phosphorylated, which suggested that α-Syn phosphorylation be connected with the occurrence of PD. Several kinds of phosphokinases can make α-Syn phosphorylated, however the precise roles of these phosphokinases in PD are less clear.
