Proton MR spectroscopy of hepatocellular carcinoma patients at 1.5 Tesla
- VernacularTitle:肝细胞癌患者1.5T氢质子磁共振波谱分析
- Author:
Peng CHEN
;
Weidong ZHAO
;
Hongyu ZHANG
;
Huijuan QIN
;
Shuai LIU
- Publication Type:Journal Article
- Keywords:
proton magnetic resonance spectroscopy;
hepatocellular carcinoma;
cirrhosis
- From:
China Oncology
2010;20(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose: Magnetic resonance spectroscopy is currently the only non-invasive magnetic resonance imaging technique which can detect metabolite composition of live organ and tissue and also conduct semi-quantitative or quantitative analysis. We analyzed the characteristics of metabolic changes among normal liver, cirrhosis regenerative nodule and liver cancer on the background of cirrhosis by voxel proton MR spectroscopy at 1.5 Tesla. Methods: 20 healthy volunteers (control group), 25 cirrhosis (cirrhosis group) and 23 hepatocellular carcinoma after cirrhosis (HCC group) patients were our candidates. The characteristics of spectra of ~1H-MRS were observed. The height and ratio of choline complex (Cbo) and lipid methylene (Lip2) were recorded and the results were compared among the groups. Results: The success rate of ~1H-MRS was about 88.2% (60/68). There were statistically significant differences among the heights of Lip2 peak of the three groups, and also between that of the control group and the group of liver cancer. But there were no significant differences between that of control group and cirrhosis group, cirrhosis group and liver cancer group. The comparison of the height of Cho peak and the ratio of Cho/Lip2 showed statistically significances both among the three groups and between each other. Conclusion: The metabolic changes of the liver could be shown non-invasively by ~1H-MRS, which could be useful for differential diagnosis or diagnosis of cirrhosis regenerative nodule and HCC.
