Clinical Study of Chromosomal Abnormalities by Puncturing Umbilical Cords
- VernacularTitle:283例脐血管穿刺诊断胎儿染色体异常临床分析
- Author:
Zheng CHEN
;
Jinghong GU
;
Yajuan HUANG
- Publication Type:Journal Article
- Keywords:
Percutaneous umbilical cord blood sampling;
Prenatal diagnosis;
Chromasomal abnormality
- From:
Journal of Practical Obstetrics and Gynecology
2010;26(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the application of puncturing the umbilical cord under the ultrasound guidance in prenatal diagnosis,clinical high risk factors of fetal chromosomal abnormalities were discussed.Methods:283 pregnant women who had the percutaneous umbilical cord blood sampling were recruited and the karyotyping was done.The detection rate of chromosomal abnormalities and correlate factors in different subgroups of prenatal diagnosis were analyzed.Results:The success rate of puncture was 100%.Major complications were bleeing at the puncture site(33 cases,11.67%)and fetal heart brachycadia(5 cases,1.77%).25 chromosomal abnormalities were found and the detection rate was 8.83%.There was significant correlation between the couple's chromosomal abnormalities and the fetal's(r=22.348,P=0.000).Conclusions:The ultrasound guided percutaneous umbilical cord blood sampling proves to be valid in the prenatal diagnosis,especially when couples have chromosomal abnormalities.
