The high mobility group protein A2 and tumor
- VernacularTitle:高迁移率族蛋白A2与肿瘤
- Author:
Guoliang YANG
;
Juanjie BO
- Publication Type:Journal Article
- Keywords:
HMGA2 protein;
neoplasm;
diagnosis;
prognosis
- From:
China Oncology
2010;20(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
The high mobility group A2 (HMGA2), one ofnon-histone chromatin proteins, may alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription factors, and leading to malignant neoplasm formation. This paper focuses on the role of the HMGA proteins in human neoplastic diseases, and discusses the mechanisms by which they contribute to carcinogenesis, and diagnosis strategies based on targeting HMGA proteins.
