Clinical Value of MR Spectroscopy in Preoperative Grading of Astrocytic Tumors
10.3969/j.issn.1002-1671.2010.01.001
- VernacularTitle:磁共振波谱在星形细胞肿瘤术前分级中的价值
- Author:
Tonggang YU
;
Jiazhong DAI
;
Huijun QIAN
;
Xiaoyuan FENG
- Publication Type:Journal Article
- Keywords:
brain;
astrocytic tumor;
MR imaging;
MR spectroscopy
- From:
Journal of Practical Radiology
2010;26(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of MR spectroscopy in preoperative grading of astrocytic tumors.Methods 52 cases with astrocytomas proved by pathology,including 20 diffuse astrocytomas,14 anaplastic astrocytomas and 18 glioblastomas,underwent MR spectroscopy with multi-voxel PRESS sequence.Results ①Astrocytic tumors were characterized by increased Cho and decreased NAA,while Lipids were present in high-grade astrocytic tumors;②Cho/Cr(r＝0.656,P=0.000),Lip1.3/Cr(r＝0.559,P=0.001) and Glx/Cr(r＝0.482,P=0.005) in the solitary tumor's regions had a significant positive correlation with the grading of astrocytic tumors, while Cho/NAA(r＝0.395,P=0.025),Lip0.9/Cr(r＝0.386,P=0.029) had a positive correlation with the tmor grading;③When Cho/Cr＝2, the sensitivity, specificity,positive predictive value and negative predictive value for diagnosis of WHO4 astrocytic tumors were 94.4%,64.3%,77.3% and 90% respectively;④When Lip1.3/Cr＝0.526, the sensitivity, specificity,positive predictive value and negative predictive value for diagnosis of WHO4 astrocytic tumors were 88.9%,92.9%,94.1% and 86.7% respectively. Conclusion MR spectroscopy is helpful in preoperative grading of astrocytic tumors.
