Study on the Correlation of Spiral CT Features with Expression of E-cadherin in Peripheral Lung Cancer
10.3969/j.issn.1002-1671.2010.01.007
- VernacularTitle:周围型肺癌的CT征象与E-cadherin表达的相关性研究
- Author:
Chuanjian Lü
;
Yamin WAN
;
Xuejun CHEN
;
Dapeng SHI
- Publication Type:Journal Article
- Keywords:
lung;
lung cancer;
tomography,X-ray computed;
E-cadherin
- From:
Journal of Practical Radiology
2010;26(1):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of spiral CT features with expression of E-cadherin(E-cad) in peripheral lung cancer.Methods Spiral CT scans were performed in 58 patients with peripheral lung cancer confirmed by pathology.Expression of E-cad in 58 cases were detected with SP immunohistochemical techniques.Spiral CT findings were compared with expression of E-cad.Results The abnormal expression of E-cad was showed in 32 cases(55.17%).The positive rates of E-cad expression were 40.63% in I-II cell differentiation group and 73.08% in III-IV cell differentiation group,and the difference was significant(P＜0.05).The abnormal expression of E-cad was associated with the CT features,such as lymph node metastasis,pleural invasion and the size of tumor(P＜0.05),but not the cavity sign,spicular sign and vessel convergence sign(P＞0.05).Conclusion E-cad gene over expression may play an important role in the pathogenesis and CT appearances of lung cancer.
