Clinical study of target-controlled infusion of propofol and remifentanil in elderly patients during the induction of general anesthesia
- VernacularTitle:老年患者全麻诱导期丙泊酚和瑞芬太尼联合靶控输注的最佳复合浓度
- Author:
Zhirong SUN
;
Shengjin GE
;
Min LI
;
Changhong MIAO
- Publication Type:Journal Article
- Keywords:
propofol;
remifentanil;
target controlled infusion;
general anasthesia;
elderly patient
- From:
Fudan University Journal of Medical Sciences
2010;37(2):216-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the best multiple concentration of target controlled infusion of propofol and remifentanil in elderly patients during the induction of general anesthesia. Methods Fifty elderly patients were randomized into five groups, according to the effect site concentration of remifentanil (0, 2, 4, 6, 8 ng/mL). We started the effect site concentration of propofol (PEC) at 2 μg/mL, and added 1 μg/mL every 2 min until bispectral index (BIS) was stable at 40±5. During the induction,we recorded the effect site concentration of remifentanil (REC) and propofol (PEC), heart rate (HR), arterial blood pressure (ABP), BIS, AAI, and isolated forearm technique (IFT). After statistic analysis, the best multiple concentration was judged. Results There was no significant difference (P<0.05) in the changes of hypertension and hypotension among these five groups during intubation. The most smooth hemodynamic conditions were found in group B, i.e. 20% and 10%, respectively. When consciousness was lost, there was a negative correlation between PEC and REC. Group B was the minimum on the change of IFT and the cardiovascular system among these five groups at tracheal intubation. Conclusions It is safe and stable to use REC 2 μg/mL for TCI, combined with propofol in elderly patients under general anesthesia. PEC is (3.5±0.8)μg/mL when the patients' consciousness is lost. And PEC is 5.3 μg/mL at tracheal intubation.
