Modified gavage methods for guinea pigs
- VernacularTitle:改良的豚鼠灌胃给药方法
- Author:
Ning CONG
;
Zhao HAN
;
Fanglu CHI
;
Juanmei YANG
;
Yibo HUANG
;
Yuan XIN
- Publication Type:Journal Article
- Keywords:
guinea pig;
gavage;
molar teeth;
anesthesia
- From:
Fudan University Journal of Medical Sciences
2010;37(2):232-235
- CountryChina
- Language:Chinese
-
Abstract:
Objective To modify the method of gavage administration in guinea pigs. Methods Fourty awake guinea pigs were kept rearing on the hind legs and leaning on a vertical fixture to avoid their escaping forward. A 1 mL injector was inserted into the mouth to the depth when the molar teeth were passed. Another fourty guinea pigs under general anesthesia were reversed at trendelenburg position and a children suction tube with an outer diameter of 2 mm was inserted into the stomach. Results All of the 80 guinea pigs were administered by modified gavage smoothly for seven consecutive days by one operator each time. None endured much pain or digestive tract injury, or died from air way perfusion by mistake. Conclusions We successfully modified the gavage method in guinea pigs, which would definitely take guinea pigs involved in intragastical pharmacal experiments besides the routine of rats and mice.
