From Minu3D cultural system to aldosterone-induced tubulogenesis
10.3969/j.issn.1673-8225-2010.02.041
- VernacularTitle:Minu3D培养系统中醛固酮诱导肾小管发生的意义
- Author:
Kanghong HU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2010;14(2):365-369
- CountryChina
- Language:Chinese
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Abstract:
The existing technical disadvantages of culture systems so far developed have limited the molecular biological study of tubulogenesis. Recently, a newly developed Minu3D system creates controllable growth conditions and allows the generation of tubules from renal stem/progenitor cells. It is for the first time indicated that aldosterone is able to induce the formation of tubules. Aldosterone may trigger some of mineralocorticoid receptor-mediated signaling'pathways for the initiation and the regulation of the tubulogenesis. The implication of these studies toward unveiling tubulogenesis is discussed.
