Animal models for traumatic brain injury and its application in experimental therapeutics
- VernacularTitle:创伤性脑损伤动物模型及其实验治疗学应用
- Author:
Bing GU
;
Jianbo JIN
;
Wei MENG
;
Yuping LI
;
Riyue YU
- Publication Type:Journal Article
- Keywords:
traumatic brain injury;
animal model;
impact brain injury;
nonimpact acceleration head injury;
blast(explosion)wave-induced neurotrauma;
experimental therapeutics
- From:
Chinese Pharmacological Bulletin
2010;26(3):285-289
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic brain injury(TBI), also known as intracranial injury or head trauma, specifically refers to the brain tissue damage caused by trauma.Currently the mechanism of TBI and repair therapy after nerve injury become a hotspot in brain research.Duplicating animal models plays a significant role in promoting experimental therapeutics of TBI.This review systematically describes the progress in animal models for TBI including impact brain injury, nonimpact acceleration head injury and blast(explosion)wave-induced neurotrauma, which have been established at home and abroad.Based upon the aforementioned models, some relevant applications in experimental therapeutics are simultaneously enumerated.Hopefully all these information provides scientific guidance for the pharmacodynamic screening of potential neuroprotective drugs.
