Research on CXCL12/CXCR4 biological axis and idiopathic pulmonary fibrosis
- VernacularTitle:CXCL12/CXCR4生物轴与特发性肺纤维化研究进展
- Author:
Hongxia CUI
;
Yizhong FENG
;
Zhenlun GU
;
Xiaogang JIANG
;
Ciyi GUO
- Publication Type:Journal Article
- Keywords:
idiopathic pulmonary fibrosis;
fibrocyte;
chemokine;
CXCL12;
CXCR4;
CXCL12/CXCR4 biological axis
- From:
Chinese Pharmacological Bulletin
2010;26(3):298-301
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis(IPF), with unknown pathogeny, is an interstitial lung disease.The pathological features are diffuse epithelial-cell lesion, fibroblast proliferation, myofibroblast differentiation and excessive extracellular matrix deposition.CXCR4 is the predominant chemokine receptor on fibrocytes;CXCL12 is the only ligand of CXCR4.A large number of studies have shown that CXCL12/CXCR4 biological axis plays an important role in the pathogenesis of idiopathic pulmonary fibrosis.Under the regulation of hypoxia, HIF-1α and PI3K-Akt-mTOR path, CXCL12/CXCR4 biological axis promotes lung fibroblast proliferation, myofibroblast differentiation and extracellular matrix deposition, resulting in development and progression of IPF.
