Methamphetamine neurotoxicity and changes of nitration in rats striatum
- VernacularTitle:甲基苯丙胺致大鼠神经毒性及纹状体硝化作用的改变
- Author:
Shuangshuang WANG
;
Minhui YANG
;
Qiong HE
;
Xiaohui TAN
;
Huijun WANG
- Publication Type:Journal Article
- Keywords:
methamphetamine;
neurotoxicity;
temperature;
nitric oxide;
nitric oxide synthase;
nitroprotein
- From:
Chinese Pharmacological Bulletin
2010;26(3):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the neurotoxicity and the changes of nitration in the striatum of rats treated with methamphetamine(MA).Methods The rats were randomly divided into MA group and control group.The stereotyped behavior and body temperature of the rats were recorded.The differences of nitric oxide, nitric oxide synthase(NOS)and nitroprotein were compared between the two groups.Results The score of stereotyped behavior and the body temperature of the rats in MA group were significantly higher than those in the control group(P ＜0.01);Compared with the control group, the content of NO and the activity of NOS of striatum in MA group were significantly increased(P ＜0.01), and nitration of protein was also upregulated(P ＜0.01).Conclusion The increases of NOS activity, NO level and nitroprotein may play an important role in MA-induced neurutoxity in rat striaturn.
