Expression of TGF-βRⅡ and fibronectin in developing mouse kidney
10.3969/j.issn.0529-1356.2010.02.023
- VernacularTitle:转化生长因子βⅡ型受体与纤维连接蛋白在小鼠肾发育中的表达
- Author:
Kun WANG
;
Li ZHANG
;
Min GUO
- Publication Type:Journal Article
- Keywords:
Transforming growth factor-β receptor typeⅡ;
Fibronectin;
Kidney;
Development;
Immunohistochemistry;
Mouse
- From:
Acta Anatomica Sinica
2010;41(2):281-284
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the chronological and spatial expressions of transforming growth factor-β receptor typeⅡ(TGF-βRⅡ)and fibronectin (Fn )in developing mouse kidney and investigate the relationship between the expressions and kidney development. Methods Immunohistochemistry and Western blotting were used to observe and measure the expression of TGF-βRⅡ and Fn in embryos and postnatal mouse kidneys. Results The expression of TGF-βRⅡ was noticed in all stages of glomeruli, renal tubes and collecting ducts, and increased gradually with ages; The expression of Fn was noticed too in all stages of glomeruli, renal tubes and collecting ducts, except for the comma-shaped bodies, and also increased gradually with ages. Conclusion TGF-β and Fn might play an important role in the development and maturation of mouse kidney.
