Applied Value of Diffusion Tensor Imaging in Early Evaluation of Prognosis of Hypoxic-Ischemic Encephalopathy in New Infants
10.3969/j.issn.1002-1671.2010.02.023
- VernacularTitle:弥散张量成像对新生儿期缺氧缺血性脑病患儿预后早期评估的应用价值
- Author:
Meili TANG
;
Sirun LIU
;
Ming YU
;
Bingxiao LI
;
Bo LIU
;
Yupin LIU
- Publication Type:Journal Article
- Keywords:
brain;
infant;
hypoxic-ischemic encephalopathy;
MR imaging
- From:
Journal of Practical Radiology
2010;26(2):241-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of diffusion tensor imaging(DTI) in early assessment of prognosis of hypoxic-ischemicencephalopathy(HIE) in new infants. Methods 96 cases of full term infants with HIE underwent DTI examinations at 0～12 days and 6～36 months. Based on clinical diagnostic criteria, 96 cases were divided into three groups: mild, moderate and severe HIE groups. Fractional anisotropy(FA) values in the corpus callosum splenium and the posterior limb of internal capsules were measured. Results (1) Varying degrees of FA groups was significantly different from the same site, increased linearly with time,but the magni-tude of change was different;(2)When FA value of corpus callosum splenium in the cut-off point was ≥0.437,the sensitivity(SE) was 83.8% , the specificity(SP) was 18.6% , ROC area under the curve was 0.903 , 95% confidence interval was from 0.846 to 0.961,standard error was 0.029;when FA value of posterior limb of internal capsule in the cut-off point ≥0.391,SE was 86.5%, SP was 11.9% ,ROC area under the curve was 0.940,95% confidence interval was from 0.898 to 0.984,standard error was 0.022. Conclusion MR DTI examination is of significant value in evaluating early the prognosis of HIE in infants.
